NB:
Paracetamol toxicity may lead to :
1- Renal failure (analgesic nephropathy).
2- Liver necrosis and damage.
3- Haemolytic anemia & methemoglobinemia.
Treatment:
1- Gastric lavage. 2- Specific antidote. 3- Supportive care for hepatic injury.
1- Gastric lavage with activated charcoal.
2- Specific antidote (Acetylcysteine):
Acetylcistein pack = Mucomyst.
Dose: 140 mg/kg oral, then 70 mg/kg/4 hours for 17 doses or until serum paracetamol level is zero.
3- Supportive care for hepatic injury.
NB: Hepatic transplantation may be required in massive liver damage.
Paracetamol toxicity may lead to :
1- Renal failure (analgesic nephropathy).
2- Liver necrosis and damage.
3- Haemolytic anemia & methemoglobinemia.
Treatment:
1- Gastric lavage. 2- Specific antidote. 3- Supportive care for hepatic injury.
1- Gastric lavage with activated charcoal.
2- Specific antidote (Acetylcysteine):
Acetylcistein pack = Mucomyst.
Dose: 140 mg/kg oral, then 70 mg/kg/4 hours for 17 doses or until serum paracetamol level is zero.
3- Supportive care for hepatic injury.
NB: Hepatic transplantation may be required in massive liver damage.
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