Ulcerative Colitis

Ulcerative Colitis

Diagnosis:

Pain → lower abdominal pain or discomfort.-

-Diarrhea → bloody ± mucus.

-Fever → may be (high in acute cases).

-Periods of remission and exacerbations.

Investigations:

-High E.S.R - high C.R.P.

-α1 Globulins – α1 glycoprotiens.

-Stool analysis → blood and may be pus.

-Barium enema → loss of haustration.
Treatment:

Mild cases: bed rest +

Valpam (diazepam) tab. 1×3 +

Lomotil (anti-motility drug to stop diarrhea) tab 1×3 +

Cefotax vial 1×2 or Quinolone antibiotic oral 1×2 or Ciprofloxacin 250 or 500 tab. 1×2.

Moderate cases: (Antidiarrheal drug + cortisone)

Colopyrine tab. Or Salazopyrine tab. As 2 tab. 4 times daily for 3 weeks with meals then 1 tab. 3 times daily for 6 monthes.

Prednisolone tab. As 1 tab. 4 times daily with lowering the dose gradually.

And best thing is to do a mixture which consists of Hydrocortisone 100 mg in 60 ml isotonic saline + Methylcellulose and give it per rectum daily for 7 days with lifting the lower limbs to make it easy for the mixture to be given then give the mixture day after day for another 7 days then stop gradually.

Severe cases: (Antidiarrheal drug + corticosteroid + cytotoxic immune suppressant drug)

Colopyrine tab. As before.

Hostacortine H = prednisolone tab. by the following method (3×3 for 1 month then 1×2 for 1 week then 1×1 for 1 week).

Imuran 50 mg tab. (1-3 mg/kg/day) = Azarin 50 mg tab.